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近年来发现大蒜具有降血脂,增加纤维蛋白溶解活性,抗血小板聚集和预防动脉粥样硬化等作用。本文就这方面的研究进展作一概述。一、大蒜的抗实验性高血脂和动脉粥样硬化作用Bordia(1975)报告大蒜油对喂饲胆固醇(0.2g/kg/d,溶于5ml牛奶中灌胃)所致家兔高胆固醇血症、高血液凝固性和主动脉脂质沉积有明显保护作用。实验进行了三个月,每天喂以新鲜提取的大蒜油(相当于生药1g/kg),可明显抑制喂饲胆固醇所致血清胆固醇和血浆纤维蛋白原含量升高、全血凝固时间缩短及主动脉脂质含量增加。此外,不仅能防止喂饲胆固醇所致的纤维蛋白溶解活性降低(7.7%),并且还能使纤维蛋白溶解活性较正常值增加27.6%。喂饲胆固醇使主动脉脂质平均含量从5.95增加到13.75mg/100mg干重,喂饲大蒜油后主动脉脂质含量甚至显著低于正常值可见大蒜油能较有效地防止家兔主动脉的脂质沉积。实验中同时用临床常用量33mg/kg/d的安妥明作对照,对上述各项参数大蒜油均明显优于安妥明。喂饲胆固醇对照组主动脉肉眼检查可见细线条状灰白色到黄色斑纹,镜捡可见空泡形成和泡沫细胞及提示早期动
In recent years, garlic has been found to have hypolipidemic effects, increased fibrinolytic activity, anti-platelet aggregation and prevention of atherosclerosis. This article gives an overview of the research progress in this area. I. Anti-experimental effects of garlic on hyperlipidemia and atherosclerosis Bordia (1975) reported that garlic oil causes hypercholesterolemia in rabbits fed cholesterol (0.2 g/kg/day dissolved in 5 ml milk). High blood coagulation and aortic lipid deposition have obvious protective effects. The experiment was carried out for three months. Freshly extracted garlic oil (equivalent to 1 g/kg crude drug) per day can significantly inhibit the increase of serum cholesterol and plasma fibrinogen levels, the shortening of the whole blood coagulation time, and the main Arterial lipid content increased. In addition, it not only prevented the decrease of fibrinolytic activity due to feeding cholesterol (7.7%), but also increased the fibrinolytic activity by 27.6% from the normal value. Feeding cholesterol increased the average aortic lipid content from 5.95 to 13.75 mg/100 mg dry weight. After feeding garlic oil, the lipid content of the aorta was significantly lower than the normal value. Visible garlic oil can effectively prevent the aorta in rabbits. Lipid deposition. Simultaneously with the clinically used amount of 33 mg/kg/d Antromine as the control, the garlic oil of the above parameters was significantly better than Antromine. Cholesterol-supplemented control group showed visible gray-white to yellow markings on the aorta by naked eye, and vacuoles and foam cells were observed on the lens and prompted early movements.