目的:用昂丹司琼对以顺铂为主的化疗方案进行预防恶心、呕吐的临床研究。方法:25例患者均为自身对照观察病例,即随机抽样,加用昂丹司琼或枢丹,第二疗程时改用对应的枢丹或昂丹司琼,其余药物均相同,以作对照观察。结果:昂丹司琼和枢丹止呕有效率分别达88％和80％,止恶心有效率分别为80％和72％,两者P>0.05,无显著差异,两者均有少数病人出现不良反应,停药后均可自行缓解。无椎体外系症状出现。结论:昂丹司琼对预防化疗病人的恶心和呕吐均有明显疗效。 OBJECTIVE: To perform clinical trials on nausea and vomiting with cisplatin-based chemotherapy regimens with ondansetron. METHODS: Twenty-five patients were all self-control observations. Random sampling was performed with Ondansetron or Gandan. When the second course of treatment was switched to the corresponding Gandan or Ondansetron, the other drugs were the same. Observed. Results: The ondansetron and shutan tetanus effective rates were 88% and 80%, respectively, and the nausea effective rates were 80% and 72%, respectively, both P>0.05, no significant difference, both have a small number of patients Adverse reactions can be relieved after withdrawal. No vertebral body symptoms appear. Conclusion: Ondansetron has significant effects in preventing nausea and vomiting in patients with chemotherapy.