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目的通过对头孢噻利致尿毒症患者抗生素脑病的药学分析与监护,发挥临床药师在治疗团队中的作用。方法分析头孢噻利的药代动力学特征、抗生素脑病出现的神经系统毒性表现及诱发的作用机制,并根据现有药物不良反应报导,提出合理用药建议。同时在抗生素脑病症状出现后及时提出解救方案,缓解患者症状。结果临床药师与临床医师共同参与治疗过程,使患者的感染症状得到控制,抗生素脑病症状缓解。结论临床药师通过参与特殊人群的药学监护,在合理用药和抗生素脑病治疗方面能够发挥重要作用。
OBJECTIVE To study the role of clinical pharmacists in the treatment team by analyzing and monitoring the antibiotic encephalopathy caused by ceftihydron in patients with uremia. Methods The pharmacokinetic characteristics of cefoselil, the neurotoxicity of the induced encephalopathy and its mechanism of action induced by antibiotic encephalopathy were analyzed. Based on the reports of adverse drug reactions, suggestions on rational drug use were proposed. At the same time in the emergence of antibiotic encephalopathy symptoms promptly put forward the rescue plan to alleviate the symptoms of patients. Results Clinical pharmacists and clinicians participated in the treatment process so that the symptoms of patients’ infection were controlled and the symptoms of antibiotic encephalopathy were relieved. Conclusion Clinical pharmacists can play an important role in the rational use of drugs and in the treatment of antibiotic encephalopathy through their participation in the pharmacy care of special populations.