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[目的]观察参七消痞方(SQ)对慢性萎缩性胃炎(CAG)大鼠组织病理形态及血清生长激素(GH)、表皮生长因子(EGF)的影响。[方法]通过N-甲基-N’-硝基-N-亚硝基胍(MNNG)综合其他因素建立CAG大鼠模型(14周),之后再随机分为模型组、摩罗丹组、叶酸组、参七消痞组。模型组给予0.9%氯化钠1ml/0.1kg灌胃,摩罗丹组摩罗丹3.6g/kg灌胃,叶酸组叶酸2mg/kg灌胃,参七消痞组参七消痞汤9g/kg灌胃,共计8周。另从实验开始造模时设立空白对照组。每周监测大鼠体重,第22周取材,观察大鼠胃病理组织学改变,测量胃窦区褶皱处胃黏膜腺体厚度(L1)/黏膜肌层厚度(L2)的比值;腹主动脉取血分离血清,放免法检测血清GH、EGF水平。[结果]参七消痞组与模型组相比,肉眼及镜下观察均大鼠胃黏膜组织病理形态有不同程度的改善,L1/L2比值提高(P<0.01);血清GH水平有升高趋势(P<0.05),血清EGF水平显著升高[(0.84±0.17)、(0.72±0.17)μg/L,P<0.01]。[结论]复方参七消痞汤能明显改善CAG大鼠的胃黏膜病变,其治疗机制可能与升高血清EGF水平有关。
[Objective] To observe the effect of SQQ on the histopathology, serum growth hormone (GH) and epidermal growth factor (EGF) in chronic atrophic gastritis (CAG) rats. [Method] CAG rat model (14 weeks) was established by combining other factors with N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), then randomly divided into model group, Group, ginseng seven Xiaopi group. Model group was given 0.9% sodium chloride 1ml / 0.1kg gavage, morodan group, the injection of morrodine 3.6g / kg gavage folic acid folic acid 2mg / kg gavage, ginseng xipi group ginseng xiaopi soup 9g / kg irrigation Stomach, a total of 8 weeks. Another from the beginning of the experiment set up a blank control group. The body weight of the rats was monitored every week. The rats were drawn at the 22nd week. The histopathological changes in the stomach were observed. The gastric mucosal gland thickness (L1) / mucosal muscular layer thickness (L2) Serum was separated from serum and radioimmunoassay was used to detect serum GH and EGF levels. [Results] Compared with the model group, the pathological changes of gastric mucosa of rats in both groups were observed under both naked eye and microscope, and the ratio of L1 / L2 was increased (P <0.01); the level of serum GH was increased (P <0.05). The level of serum EGF was significantly increased (0.84 ± 0.17) and (0.72 ± 0.17) μg / L, respectively, P <0.01]. [Conclusion] Fufang Shenqi Xiaopi Decoction can significantly improve gastric mucosal lesions in CAG rats, and its therapeutic mechanism may be related to increasing serum EGF level.