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目的探讨川芎嗪联合尼莫地平治疗脑缺血再灌注损伤的机制。方法采用Bannister’s方法复制大鼠脑缺血再灌注动物模型,利用川芎嗪或川芎嗪联合尼莫地平治疗;在透射电镜下观察皮质神经元超微结构变化。结果模型组神经元水肿,质膜、线粒体膜破裂;溶酶体、内质网和高尔基复合体破坏。治疗组神经元质膜、核膜、内质网及线粒体损伤减轻,川芎嗪联合尼莫地平治疗效果更佳。结论川芎嗪及川芎嗪联合尼莫地平对脑缺血再灌注神经元有明显的保护作用。
Objective To investigate the mechanism of ligustrazine and nimodipine in treating cerebral ischemia-reperfusion injury. Methods The rat model of cerebral ischemia-reperfusion was established by Bannister’s method. The rats were treated with ligustrazine or ligustrazine together with nimodipine. The ultrastructure of cortical neurons was observed under transmission electron microscope. Results The model group had neuron edema, plasma membrane and mitochondrial membrane rupture; the destruction of lysosome, endoplasmic reticulum and Golgi complex. Treatment group neurons plasma membrane, nuclear membrane, endoplasmic reticulum and mitochondrial lesion reduced, ligustrazine combined with nimodipine treatment effect is better. Conclusion Tetramethylpyrazine and tetramethylpyrazine combined with nimodipine have significant protective effect on neurons after cerebral ischemia-reperfusion.