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目的 探讨酚妥拉明、甘利欣联合治疗慢性重度淤胆型肝炎的降黄疗效。方法 将我院同期慢性重度淤胆型肝炎患者随机分为治疗组 86例 (用酚妥拉明、甘利欣联合治疗 ) ,对照组 82例 (用复方丹参、门冬氨酸钾镁治疗 ) ,观察治疗前后血清胆红素的变化情况。结果 治疗组血清胆红素降低显著 ,总有效率 81.3 6% ,与对照组相比有显著差异 (P <0 .0 1)。结论 酚妥拉明、甘利欣联合治疗慢性重度淤胆型肝炎降黄疗效显著 ,副作用少 ,简便实用。
Objective To investigate the efficacy of phentolamine and melixin combined in the treatment of chronic severe cholestatic hepatitis. Methods The patients with chronic severe cholestatic hepatitis at the same period in our hospital were randomly divided into treatment group (n = 86) treated with phentolamine and melixin, control group (n = 82) treated with compound Salvia miltiorrhiza and potassium magnesium aspartate Observe the changes of serum bilirubin before and after treatment. Results Serum bilirubin decreased significantly in treatment group with a total effective rate of 81.36%, which was significantly different from that in control group (P <0.01). Conclusions Phentolamine and Glycyrrhizin combined in the treatment of chronic severe cholestatic hepatitis have significant effects of reducing yellowness, fewer side effects, and are simple and practical.