应用SpA菌苗治疗11例恶性肿瘤;其中膀胱灌注5例,腹腔注射2例,瘤块内注射4例。前两种方法未见有副作用,但除一例膀胱癌术后配合菌苗灌注后4年没有复发外,其余无明显疗效。4例瘤块内注射,3例无明显改善,1例肿瘤约缩小30％;值得注意的是,这种使用途径,有2例(50％)产生较严重的过敏反应。11例应用SpA菌苗后,血清中的IgG和IgA明显升高,但OKT3、OKT4和OKT8标志的淋巴细胞均无显著改变。 SpA bacterin was used to treat 11 cases of malignant tumors, including 5 cases of intravesical instillation, 2 cases of intraperitoneal injection and 4 cases of intratumoral injection. There were no side effects in the first two methods, but there was no obvious effect except one case in which no recurrence occurred after 4 years of bladder cancer infusion with bacterin perfusion. 4 cases were injected intratumorally, 3 cases had no obvious improvement, and 1 case had a tumor reduction of 30%. It is noteworthy that 2 cases (50%) of this route of use produced severe allergic reactions. After the SpA vaccine was applied in 11 cases, the serum IgG and IgA were significantly increased, but there were no significant changes in the lymphocytes marked by OKT3, OKT4 and OKT8.