论文部分内容阅读
IDH1基因突变在胶质瘤中很常见,同时产生D-2-羟戊二酸(D-2-HG)。IDH1突变对胶质瘤的生物学行为和肿瘤微环境的具体影响尚不清楚。作者收集的169例WHOⅡ~Ⅳ级的胶质瘤和148例已验证病例,分析IDH1突变、肿瘤内微血栓和静脉血栓栓塞(VTE)。作者还分析了癌症基因组图谱计划中的430例胶质瘤中凝血相关基因的m RNA,评估了95例组织芯片中的组织因子蛋白表达。在IDH1突变或
IDH1 mutations are common in gliomas, producing D-2-hydroxyglutarate (D-2-HG). The exact impact of IDH1 mutations on the biological behavior of gliomas and the tumor microenvironment is unclear. The authors collected 169 cases of grade Ⅱ ~ Ⅳ glioma and 148 cases have been verified cases of IDH1 mutations, micro-thrombosis and venous thromboembolism (VTE). The authors also analyzed m RNA of coagulation-related genes in 430 gliomas in the cancer genome mapping project and evaluated tissue factor protein expression in 95 tissue chips. IDH1 mutations or