4-芳基香豆素类化合物又名新黄酮,广泛存在于天然产物中,研究表明该类化合物具有细胞毒性、抗氧化、抗菌、抗炎等多种药理活性。随着其生物活性及构效关系的深入研究,其合成方法的研究也成为热点之一。本文对4-芳基香豆素类化合物的活性及有效合成方法进行综述,以期为发现新型药物先导化合物提供借鉴。 4-arylcoumarins, also known as new flavonoids, are widely found in natural products. Studies have shown that these compounds have many pharmacological activities such as cytotoxicity, anti-oxidation, antibacterial and anti-inflammatory. With its biological activity and structure-activity relationship in-depth study, the synthesis of research has become one of the hot spots. In this paper, the activity of 4-arylcoumarins and effective synthesis methods are reviewed in order to provide reference for the discovery of new lead compounds.