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为了研究红细胞增多对缺氧性肺动脉高压和右室肥大的影响,将大鼠分为四组:常氧对照组;单纯红细胞增多组;慢性缺氧组;慢性缺氧复合红细胞增多组。结果表明,单纯红细胞增多引起右室V_(max)、右室收缩压和右室重量指数增加。慢性缺氧不仅引起右室±dP/dt_(max)和V_(max)增加,还引起右室收缩压和右室重量指数增加。慢性缺氧复合红细胞增多进一步使右室收缩压和右室重量指数增加。此外,还出现左室重量指数增加。以上结果表明,红细胞增多在缺氧性肺动脉高压和右室肥大中起着重要作用。
In order to investigate the effect of erythrocyte on hypoxic pulmonary hypertension and right ventricular hypertrophy, the rats were divided into four groups: normoxia control group, pure polycythemia group, chronic hypoxia group and chronic hypoxia combined polycythemia group. The results showed that simple erythrocyte increased right ventricular V max, right ventricular systolic pressure and right ventricular mass index increased. Chronic hypoxia not only caused an increase of ± dP / dt max and V max in the right ventricle, but also caused an increase of RV systolic pressure and RV weight index. Chronic hypoxemia combined with erythrocyte further increases right ventricular systolic pressure and right ventricular mass index. In addition, there is also an increase in LV mass index. The above results show that increased red blood cells in hypoxic pulmonary hypertension and right ventricular hypertrophy play an important role.