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目的观察恩度联合肝动脉化疗栓塞(TACE)对肝癌术后VEGF表达的影响。方法 70例确诊肝癌行根治性切除且预防性行TACE患者中,恩度联合TACE治疗25例为试验组,单纯行TACE治疗45例为对照组,所有患者采用ELISA法在术前和术后3d及1、2、3、4、5周检测血清VEGF水平。结果两组术后3d内VEGF呈上升趋势,3d~2周内VEGF均呈下降趋势。2周后试验组继续稳定下降,而对照组却有上升趋势,术后两组3、4、5周VEGF水平比较有统计学差异(P<0.05)。结论恩度联合TACE具有降低VEGF表达和抑制肿瘤血管生成的作用。
Objective To observe the effect of Endo combined with transcatheter arterial chemoembolization (TACE) on VEGF expression in postoperative liver cancer. Methods Totally 70 TCC patients with hepatocellular carcinoma who underwent radical resection and prophylactic TACE were enrolled in this study. Enamel combined with TACE was used as the experimental group. TACE alone was performed in 45 patients as control group. All patients were treated with TACE before and 3 days And 1,2,3,4,5 weeks serum VEGF levels were detected. Results The levels of VEGF in both groups increased on the 3rd postoperative day and decreased on the 3rd and 2nd week. After 2 weeks, the experimental group continued to decline steadily, while the control group had an upward trend. The levels of VEGF in the two groups at 3, 4, and 5 weeks after operation showed statistically significant difference (P <0.05). Conclusions Endo combined with TACE can reduce VEGF expression and inhibit tumor angiogenesis.