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目的:探讨肿瘤标志物CA19-9、CA242、CA125及CEA在胆管癌诊断中的价值。方法:采用蛋白芯片-化学发光法对68例胆管癌患者血清肿瘤标志物CA19-9、CA242、CA125及CEA进行检测。结果:胆管癌患者血清CA19-9、CA242、CA125及CEA阳性率分别为73.53%,58.82%,25.00%,13.24%,而联合检测阳性率为80.89%。结论:CA19-9对胆管癌诊断具有较好应用价值,联合检测肿瘤标志物CA19-9、CA242、CA125及CEA在一定程度上可以提高胆管癌诊断敏感性。
Objective: To investigate the value of tumor markers CA19-9, CA242, CA125 and CEA in the diagnosis of cholangiocarcinoma. Methods: The serum tumor markers CA19-9, CA242, CA125 and CEA in 68 patients with cholangiocarcinoma were detected by protein chip - chemiluminescence method. Results: The positive rates of serum CA19-9, CA242, CA125 and CEA in patients with cholangiocarcinoma were 73.53%, 58.82%, 25.00% and 13.24%, respectively. The positive rate of combined detection was 80.89%. Conclusion: CA19-9 has a good application value in the diagnosis of cholangiocarcinoma. Combined detection of tumor markers CA19-9, CA242, CA125 and CEA can improve the diagnostic sensitivity of cholangiocarcinoma to a certain extent.