论文部分内容阅读
乳房外Paget病又名乳房外湿疹样癌(EMPD),是一种临床上罕发的皮肤特殊类型恶性肿瘤,肿瘤好发部位多为外生殖器,男性见于阴囊或阴茎,女性见于大、小阴唇和阴道,也有少数病例可发生于肛门周围、腹股沟、或腋窝处。关于该病的研究较少,因此无法明确地解释EMPD的发病机制。相关学说有皮肤附属器起源学说,异位细胞起源学说及肿瘤迁移学说等,本文综述这些学说,以求探讨出EMPD发病机制的合理解释。
Extramammary Paget disease, also known as extramammary eczema-like carcinoma (EMPD), is a clinically rare type of skin specific malignancies, the site of the tumor is mostly genital, men found in the scrotum or the penis, the female found in the large labia minora And the vagina, there are a few cases can occur around the anus, groin, or armpits. There are few studies on this disease and therefore the exact pathogenesis of EMPD can not be clearly explained. Relevant theories include the theory of the origin of skin appendages, the theory of ectopic origin of cells and the theory of tumor migration. This article reviews these theories in order to explore a reasonable explanation of the pathogenesis of EMPD.