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目的观察大鼠电惊厥后脑内生长抑素受体的变化。方法应用受体结合放射自显影术、计算机显微图象处理技术观测。结果正常大鼠大脑皮层、杏仁核、新纹状体、伏膈核、海马CA区、齿状回、嗅球、弓状核、下丘脑室周区、下丘脑腹内侧核、视前区内侧区、中央灰质、黑质等脑区内有125I-Tyr11-SS28特异性结合;电惊厥后,大鼠颞叶听皮质、梨状皮质、内嗅皮质、杏仁内侧核、海马CA区、齿状回、下丘脑腹内侧核等脑区125I-Tyr11-SS28的特异性结合比正常大鼠显著增加(P<0.05)。结论电惊厥的发作可能与不同脑区内生长抑素受体的上调有关。
Objective To observe the changes of somatostatin receptors in the brain after electrical shock in rats. Methods Receptors combined with autoradiography and computer microscopic image processing techniques were used. Results Normal rat cerebral cortex, amygdala, new striatum, phrenic nucleus, hippocampal CA area, dentate gyrus, olfactory bulb, arcuate nucleus, hypothalamic ventricular zone, hypothalamic ventromedial nucleus, medial preoptic area , Central gray matter, substantia nigra and other brain regions 125I-Tyr11-SS28 specific binding; electrical convulsion, the temporal cortex of the rat auditory cortex, piriform cortex, entorhinal cortex, medial almond nucleus, hippocampal CA area, dentate gyrus , And the specific binding of 125I-Tyr11-SS28 in hypothalamic ventrolateral medulla increased significantly (P <0.05) compared with normal rats. Conclusion The onset of electroconvulsions may be related to the upregulation of somatostatin receptors in different brain regions.