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为克服大黄素循环周期短、毒副作用大等缺点,本研究以Mg-Zn-Al型层状双金属氢氧化物(Mg-Zn-Al-LDHs)为前驱体,采用二次组装法将大黄素分子成功插入到Mg-Zn-Al-LDHs层间,并探讨了反应温度和原料配比等因素对该纳米杂化物载药量的影响。XRD结果显示,随样品载药量增加,Mg-Zn-Al-LDHs粒子层间距由0.48 nm增大到3.42 nm。分别在pH4.8和pH7.5的缓冲溶液中测定了大黄素/LDHs的缓释性能,结果表明大黄素/LDHs的药品释放速率明显低于二者的物理混合物中的药品释放速率。本研究还探讨了大黄素/LDHs的释放机理,实验数据表明:在pH7.5时,大黄素的释放行为受扩散过程控制;在pH4.8时,层间药物主要通过载体的溶解释放出来。
In order to overcome the short cycle of emodin cycle and large toxic and side effects, this study used the Mg-Zn-Al layered double hydroxide (Mg-Zn-Al-LDHs) Zn-Al-LDHs were successfully inserted into the interlayer of Mg-Zn-Al-LDHs. The effects of reaction temperature, raw material ratio and other factors on the drug loading of the nano-hybrid were discussed. XRD results showed that the particle spacing of Mg-Zn-Al-LDHs particles increased from 0.48 nm to 3.42 nm with the increase of drug loading. The sustained-release properties of emodin / LDHs were measured in buffer solutions of pH 4.8 and pH 7.5, respectively. The results showed that the drug release rates of emodin / LDHs were significantly lower than those of the physical mixtures. The mechanism of release of emodin / LDHs was also investigated in this study. The experimental data show that the release of emodin is controlled by the diffusion process at pH 7.5; at pH 4.8, the intercalation drug is released mainly by the dissolution of the carrier.