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C型肉毒梭茵毒素(以下简称毒素)是高分子蛋白质,易溶于水,酸性环境较稳定。毒性机理是一种嗜神经性麻痹毒素。鼠类进食毒饵、毒素由胃肠道吸收进入血液循环,作用于颅脑神经和外周神经末梢,导致肌肉麻痹。表现为神经萎糜、食欲废绝,全身瘫痪,最后死于呼吸麻痹。死亡时间与毒素中毒量有关,一般进食毒饵后的第3～5天死亡。对人、畜、禽比较安全。不伤害鼠类天敌和非靶动物,无二次中毒,不污染环境等优点。 一、材料与方法 1、材料:试验药物C型肉毒梭菌毒素,由青海省兽医生物药品制造厂提供。 2、方法:用2‰浓度毒素和粉碎玉米拌成毒饵。加工毒饵时每小时搅拌1次,毒素完全被基饵吸收为
Clostridium botulinum type C toxin (hereinafter referred to as toxin) is a polymer protein, soluble in water, acidic environment is more stable. The toxic mechanism is a neurotropic paralysis toxin. Murine bait, toxins absorbed into the bloodstream by the gastrointestinal tract, acting on the cranial nerves and peripheral nerve endings, leading to muscle paralysis. Manifested as neurotic wilting, loss of appetite, systemic paralysis, and finally died of respiratory paralysis. The time of death is related to the amount of toxin poisoning, and generally dies on the 3rd to 5th days after consuming the bait. On people, livestock, poultry safer. Do not hurt the mouse natural enemies and non-target animals, no secondary poisoning, do not pollute the environment and so on. First, materials and methods 1, materials: C drug test drug Clostridium botulinum toxin, provided by the veterinary biopharmaceutical manufacturer in Qinghai Province. 2, method: with 2 ‰ concentration of toxins and corn smashed into bait. Agitation bait 1 hour per hour, the toxin is completely absorbed by the bait