论文部分内容阅读
众所周知,血液凝固机制包括了血小板、血浆凝血因子及血管内皮细胞之间十分复杂的相互作用。凝血因子能藉内源性和外源性两条反应途径依次活化,将可溶的纤维蛋白原转变成不溶的纤维蛋白多聚体,进而网罗红细胞并稳定血小板聚集所形成的栓块,阻止受创部位继续出血。在内源性凝血途径中,X因子的活化仰赖于Ⅸ因子的激活及Ⅷ因子的协调作用。Ⅸ因子和Ⅷ因子分别由Ⅺa和凝血酶激活。活化的Ⅷ因子与磷脂、钙离子一道,可大大增强Ⅸa因子的催化活性,因此它是内源性凝血途径的一个非常重要的调节因素。Ⅷ和Ⅸ
It is well-known that blood coagulation mechanisms include very complex interactions between platelets, plasma clotting factors and vascular endothelial cells. Clotting factors can be activated endogenously and exogenously by two reaction pathways, which convert soluble fibrinogen into insoluble fibrin polymers, which in turn block red blood cells and stabilize the lumps formed by platelet aggregation, preventing Create a site to continue bleeding. In the intrinsic coagulation pathway, factor X activation depends on the activation of factor Ⅸ and Ⅷ factor coordination. Factor IX and factor VIII are activated by XIa and thrombin, respectively. Activated factor Ⅷ together with phospholipids and calcium ions can greatly enhance the catalytic activity of factor IXa, so it is a very important regulator of endogenous coagulation pathway. Ⅷ and Ⅸ