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目的 研究家兔糖皮质激素受体 (GR)与激素性青光眼 (SIG)的关系。方法 实验前测定家兔外周血白细胞糖皮质激素受体 (GR)、血浆皮质醇 ,实验中隔日给家兔结膜下注射地塞米松 0 .5 mg,共 15次 ,30 d,每周测量家兔眼压、房水流畅系数 C值 1次 ,分析GR、血浆皮质醇与眼压、C值的改变值间的关系。结果 GR与眼压、C值的改变值间具有相关性 (P<0 .0 2 5 ,P<0 .0 1) ,血浆皮质醇与眼压、C值的改变值间无相关性 (P>0 .0 5 )。结论 GR的水平与眼组织对糖皮质激素的敏感性有关
Objective To investigate the relationship between glucocorticoid receptor (GR) and steroid-induced glaucoma (SIG) in rabbits. Methods Rabbit peripheral blood leukocyte glucocorticoid receptor (GR) and plasma cortisol were measured before experiment. The rabbits were injected subconjunctivally with 0.5 mg dexamethasone for 15 days and 30 days every other day. Rabbit intraocular pressure, aqueous fluid coefficient C value of 1 times, analysis of GR, plasma cortisol and intraocular pressure, C value changes in the relationship between. Results There was a significant correlation between GR and changes of intraocular pressure and C value (P <0.05, P <0.01), and there was no correlation between plasma cortisol and changes of intraocular pressure and C value (P > 0 .0 5). Conclusion The level of GR is related to the sensitivity of eye tissue to glucocorticoid