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目的观察不同分型脑外伤患者急性期外周血炎性细胞因子表达变化。方法89例不同分型(根据格拉斯哥昏迷评分,GCS)脑外伤患者急性期接受了外周血炎性细胞因子(TNF-α、IL-1、IL-6和IL-8)检测。结果中、重型脑外伤组(GCS评分≤12分,34例)颅脑损伤患者入院后第1天和第7天血清TNF-α、IL-1、IL-6和IL-8浓度均明显高于轻型(GCS评分13～15分,55例)。结论中、重型脑外伤患者急性期外周血炎性细胞因子表达强烈。
Objective To observe the changes of peripheral blood inflammatory cytokines in patients with different types of traumatic brain injury. Methods A total of 89 patients with different traumatic brain injury (GCS) were enrolled in this study. Peripheral blood inflammatory cytokines (TNF-α, IL-1, IL-6 and IL-8) were measured in acute phase. Results Serum levels of TNF-α, IL-1, IL-6 and IL-8 were significantly higher in patients with severe traumatic brain injury (GCS score ≤12 points, 34 cases) on the first day and the seventh day after admission In the light (GCS score 13 to 15 points, 55 cases). Conclusions The expression of inflammatory cytokines in peripheral blood in patients with severe traumatic brain injury in acute phase is strong.