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本研究应用pH监测系统探讨功能性消化不良(FD,n=12)患者昼夜胃内pH变化,并以健康组(HT,n=9)和十二指肠溃疡(DU,n=10)作为对照。结果表明FD组白天和夜间胃内pH<1的时间分别为27.8±7.0％和12.9±4.4％,与HT组的差别不大(11.4±5.6％,P>0.05,8.3±3.2％,P>0.05),但明显低于DU组(48.8±5.9％,P<0.01,58.5±7.2％,P<0.01);FD组白天胃内pH>3的时间与HT组相近(分别为33.9±7.5％,34.5±8.0％,P>0.05),大于DU组(20.7±3.9％,P<0.01)。33.3％的FD者餐后pH值不上升,高于HT组(7.4％,P<0.05)和DU组(3.3％,P<0.05),FD组夜间pH>4的总时间、所占的％和最长持续时间分别为223.6±45.9min、46.5％和164±41.5min,大于HT组但差别不大(169.7±40.2min、32±6.8％和105.0±22.6min,P值均<0.05),明显大于DU组(57.6±12.0min、10.4±4.3％和44.1±10.0min,P值均<0.05)。本研究表明FD患者并无高酸分泌,因而对FD患者应寻找更合适的治疗。FD患者夜间pH值>4的时间明显延长,提示可能存在十二指肠胃反流,但应作进一步研究。
In this study, we used pH monitoring system to study the intra-day and night gastric pH changes in patients with functional dyspepsia (FD, n = 12). Healthy group (HT, n = 9) and duodenal ulcer Control. The results showed that the intragastric pH <1 in FD group during daytime and nighttime were 27.8 ± 7.0% and 12.9 ± 4.4% respectively, which was not significantly different from HT group (11.4 ± 5.6%, P> 0.05, 8.3 ± 3.2%, P> 0.05), but significantly lower than that of the DU group (48.8 ± 5.9%, P <0.01, 58.5 ± 7.2%, P <0.01) , 34.5 ± 8.0%, P> 0.05), which was higher than that in DU group (20.7 ± 3.9%, P <0.01). 33.3% of the FD patients did not have an increased pH after meal, which was higher than that of the HT group (7.4%, P <0.05) and DU group (3.3%, P <0.05) And the longest duration were 223.6 ± 45.9min, 46.5% and 164 ± 41.5min respectively, which were significantly higher than those in HT group (169.7 ± 40.2min, 32 ± 6.8% and 105.0 ± 22.6min, P <0.05 respectively) (57.6 ± 12.0 min, 10.4 ± 4.3% and 44.1 ± 10.0 min, P <0.05). This study shows that patients with FD have no hypersecretion and therefore should seek more appropriate treatment for patients with FD. Patients with FD at night time pH> 4 significantly prolonged, suggesting that there may be duodenal reflux, but should be further studied.