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目的通过调查食管癌高发区60 181例患者及父母、同胞食管癌和贲门癌患病情况,了解夫妻不同患病类型(双发、单发和正常)与子女发病关系,加深对食管癌遗传倾向性的认识。方法研究对象来自我们实验室食管癌和贲门癌资料库,采用卡方检验和Logistic回归方法,比较夫妻不同患病类型的发生率与其子女食管癌和贲门癌的患病风险。结果与正常夫妻相比,夫妻均为食管癌和/或贲门癌患者的子女≥2人患食管癌和贲门癌的风险升高近12倍(13.79%,1.32%,P<0.05,OR=11.867,95%CI=9.026～15.601),单发(妻)患者的子女≥2人患癌风险升高近10倍(11.93%,1.32%,P<0.05,OR=10.042,95%CI=8.357～12.067),单发(夫)患者的子女≥2人患癌风险升高近9倍(10.63%,1.32%,P<0.05,OR=8.817,95%CI=7.419～10.479)。结论夫妻癌和单发(夫/妻)癌其子女≥2人患食管癌或贲门癌的几率明显高于正常夫妻的子女,提示了遗传因素对食管癌和/或贲门癌癌变具有重要的影响。
Objective To investigate the prevalence of esophageal cancer and esophageal cancer in 60 181 high incidence esophageal cancer patients and their esophageal cancer and cardia cancer, to understand the relationship between the different prevalence types of husband and wife (twin, solitary and normal) and their children, and to deepen their genetic predisposition toward esophageal cancer Sexual understanding. Methods The subjects were from our laboratory esophageal and cardia cancer databases. The incidence of esophageal and cardia cancers was compared between the incidence of different types of diseases and the incidence of esophageal and cardiac cancer by chi-square test and Logistic regression. Results Compared with normal couples, the risk of esophageal cancer and cardia cancer in couples with esophageal cancer and / or cardia cancer was almost 12 times higher than those with esophageal cancer and / or cardia cancer (13.79%, 1.32%, P <0.05, OR = 11.867 , 95% CI = 9.026 ~ 15.601). The risk of cancer ≥10 in women with single wife was nearly 10 times higher than those in single women (11.93% vs 1.32%, P <0.05, OR = 10.042, 95% CI = 8.357 ~ 12.067). The risk of developing cancer was nearly 9 times higher in children with single disease (10.63%, 1.32%, P <0.05, OR = 8.817, 95% CI = 7.419-10.479). Conclusion The incidence of esophageal cancer or cardia cancer in couples and couples with their children ≥ 2 is significantly higher than that of normal couples, suggesting that genetic factors have a significant impact on the carcinogenesis of esophageal and / or cardiac cancer .