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目的:观察不同剂量氨茶碱治疗小儿哮喘的临床疗效及安全性。方法:对103例患哮喘的儿童使用不同剂量的氨茶碱进行治疗,监测用药前后患儿的症状体征,各肺功能指标及不良反应次数和程度。结果:组内比较:五组给药比治疗前都能提高患儿的第一秒用力呼气容积(FEV1)和最大呼气流速(PEP),且比较有统计学差异(P<0.05);组间比较:氨茶碱给药组比对照组提高FEV1和PEP更明显,其中以氨茶碱剂量2组最为显著,其次是氨茶碱剂量3组和1组,比较有统计学差异(P<0.05)。结论:口服氨茶碱剂量为5mg/kg/d,治疗小儿哮喘效果最显著,且安全性好。
Objective: To observe the clinical efficacy and safety of different doses of aminophylline in the treatment of pediatric asthma. Methods: A total of 103 children with asthma were treated with different doses of aminophylline. The symptoms and signs, the indexes of lung function and the frequency and degree of adverse reactions in children were monitored before and after treatment. Results: Comparison of the two groups showed that FEV1 and PEP of the five groups were all improved before treatment compared with the control group (P <0.05). Comparison between groups: aminophylline administration group than the control group to improve FEV1 and PEP more obvious, of which the aminophylline dose two groups the most significant, followed by aminophylline dose of three groups and one group, there was a statistically significant difference (P <0.05). Conclusion: The dosage of oral aminophylline is 5mg / kg / d, the most effective treatment of pediatric asthma, and good safety.