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目的检测乳腺癌组织内NF-κBp65、VEGF-C及受体VEGFR-3的表达水平,并观察它们与临床病理特征的关系,为乳腺癌的早期诊断、治疗提供依据。方法采用免疫组化染色法检测50例乳腺癌组织及10癌旁组织内NF-κBp65、VEGF-C及受体VEGFR-3的表达,并分析与临床病理因素的关系。结果乳腺癌组织内NF-κBp65蛋白表达的阳性率为76.0%,明显高于癌旁对照组织30.0%,二者相比差异显著(P<0.05);乳腺癌组织内VEGF-C蛋白表达的阳性率为84.0%,明显高于癌旁对照组织20.0%,二者相比差异显著(P<0.05);乳腺癌组织内VEGFR-3蛋白表达的阳性率为88.0%,明显高于癌旁对照组VEGFR-3阳性表达率20.0%,两者相比差异显著(P<0.05);乳腺癌组织内NF-κBp65、VEGF-C及受体VEGFR-3三者的表达存在显著相关性(P<0.05),均与肿瘤淋巴转移密切相关(P<0.05),而与病人年龄、肿瘤大小无关(P>0.05)。结论乳腺癌中NF-κBp65的表达可能上调VEGF-C的表达,进而导致肿瘤周围淋巴管增生、扩张,促进肿瘤细胞向区域淋巴结转移。
Objective To detect the expression of NF-κBp65, VEGF-C and VEGFR-3 in breast cancer and to observe their relationship with clinicopathological features and provide the basis for the early diagnosis and treatment of breast cancer. Methods Immunohistochemical staining was used to detect the expression of NF-κBp65, VEGF-C and VEGFR-3 in 50 cases of breast cancer tissues and 10 adjacent tissues, and to analyze the relationship with clinicopathological factors. Results The positive rate of NF-κBp65 expression in breast cancer tissues was 76.0%, which was significantly higher than that in adjacent non-cancerous tissues (30.0%) (P <0.05). The positive expression of VEGF-C in breast cancer tissues (P <0.05). The positive rate of VEGFR-3 protein expression in breast cancer tissues was 88.0%, which was significantly higher than that in adjacent non-cancerous tissues The positive rate of VEGFR-3 was 20.0%, which was significantly different between the two groups (P <0.05). There was a significant correlation between the expression of NF-κBp65, VEGF-C and VEGFR- ) Were closely related to tumor lymphatic metastasis (P <0.05), but not to patient age and tumor size (P> 0.05). Conclusion The expression of NF-κBp65 in breast cancer may up-regulate the expression of VEGF-C, leading to the proliferation and expansion of lymphatic vessels around the tumor and promoting the metastasis of tumor cells to the regional lymph nodes.