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基质金属蛋白酶(matrix metalloproteinases,MMPs)是一种与蝌蚪尾巴退化有关的间质蛋白酶,由Gross在1962年首次发现,并将其命名为MMP-1。随后按其发现的顺序,MMPs家族已命名至MMP-28。越来越多的资料证实,MMPs是一类依赖于锌和钙离子的蛋白水解酶,主要的生理作用是降解细胞外基质(extracellular matrix,ECM),如胶原、层粘连蛋白和纤粘连蛋白等。MMPs主要由巨噬细胞、中性粒细胞、平滑肌细胞和内皮细胞产生,当这些细胞受外界特定信号刺激时,促使MMPs合成增加并分泌至ECM。MMPs与多发性硬化(multiple sclerosis,MS)的关
Matrix metalloproteinases (MMPs), a type of stromal protease associated with tadpole tail degeneration, were first discovered by Gross in 1962 and named as MMP-1. The MMPs family has subsequently been named MMP-28 in the order of their discovery. More and more data confirm that MMPs are a class of proteolytic enzymes that depend on zinc and calcium ions. The main physiological role is to degrade the extracellular matrix (ECM), such as collagen, laminin and fibronectin . MMPs are mainly produced by macrophages, neutrophils, smooth muscle cells and endothelial cells. When these cells are stimulated by specific signals from the outside world, MMPs promote the synthesis and secretion of MMPs to the ECM. MMPs and multiple sclerosis (multiple sclerosis, MS) off