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目的探讨老年冠心病(CHD)患者血清血栓素B2(TxB2)、6-酮-前列腺素F1α(6-K-PGF1α)水平和凝血酶原时间国际标准化比率(PTINR)的变化,及阿司匹林对其的干预影响。方法采用放射免疫法测定60例CHD患者和30例非冠心病患者的血清TxB2、6-K-PGF1α水平,生化法测定PTINR,对老年CHD组给予阿司匹林治疗,4周后复查上述指标,并进行对照分析。结果老年CHD组血清TxB2水平显著高于对照组(P<0.01),6-K-PGF1α水平和PTINR显著低于对照组(P均<0.01)。TxB2与PTINR呈负相关(r=-0.472,P<0.01),TxB2与6-K-PGF1α及PTINR与6-K-PGF1α间均无相关性(P均>0.05),Ⅰ、Ⅱ、Ⅲ和Ⅳ级心功能组间变化差异均无统计学意义(P均>0.05)。经平均36.2d的阿司匹林(拜阿司匹林)干预治疗后,老年CHD组血清TxB2水平显著下降(P<0.05),PTINR值显著升高(P<0.01),但6-K-PGF1α水平无明显改变(P>0.05)。结论老年CHD患者血清TxB2和PTINR显著增高,6-K-PGF显著下降,阿司匹林的干预治疗有助于改善此状态。
Objective To investigate the changes of serum TXB2, 6-K-PGF1α and PTINR in elderly patients with coronary heart disease (CHD) and the relationship between aspirin The impact of intervention. Methods Serum levels of TxB2, 6-K-PGF1α in 60 CHD patients and 30 non-CHD patients were measured by radioimmunoassay. PTINR was determined by biochemical method. Aspirin was given to the elderly CHD group. After 4 weeks, the above indexes were reviewed. Control analysis. Results The levels of TxB2 in elderly CHD group were significantly higher than those in control group (P <0.01). The levels of 6-K-PGF1α and PTINR were significantly lower than those in control group (all P <0.01). TxB2 was negatively correlated with PTINR (r = -0.472, P <0.01). There was no correlation between TxB2, 6-K-PGF1α, PTINR and 6-K-PGF1α There was no significant difference in the changes of grade Ⅳ heart function group (all P> 0.05). After 36.2 days of aspirin treatment, the level of TxB2 in elderly CHD group was significantly lower (P <0.05) and PTINR was significantly higher (P <0.01), but the level of 6-K-PGF1α was not significantly changed P> 0.05). Conclusion Serum levels of TxB2 and PTINR are significantly increased in elderly CHD patients, while 6-K-PGF is significantly decreased. Aspirin intervention therapy may help to improve this condition.