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AIDS病人常伴有危及生命的隐球菌感染.基础治疗缓解后如不进行维持治疗则预后差,复发率也高.两性霉素B(AmB,0.3～0.7mg/d,3～22周)或单用或与氟胞嘧啶(75～150mg/(kg·d))联用是公认的治疗AIDS隐球菌感染的一线药物.作者主要研究了短程(2周)大剂量AmB(lmg/(kg·d))加氟胞嘧啶100mg/(kg·d)治疗AIDS隐球菌性脑膜炎(CM)和脑膜外播散性隐球菌感染(EMC)的疗效及安全性.
AIDS patients are often associated with life-threatening cryptococcal infections, poor prognosis and high recurrence rates without maintenance therapy after remission of basic treatment Amphotericin B (AmB, 0.3-0.7 mg / d for 3-22 weeks) or The combination of flucytosine (75-150 mg / (kg · d)) alone is recognized as the first-line drug for the treatment of Cryptococcus neoformans infection. The authors studied the effects of short-term (2 weeks) high-dose AmB d)) treatment with flucytosine 100 mg / (kg · d) for the treatment of cryptococcal meningitis (CM) and extracapsular disseminated cryptococcosis (EMC).