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目的:探讨电化学疗法对TA2系小鼠B 细胞淋巴瘤的抑制作用和死亡率的影响。方法:用移植的方法复制小鼠B细胞淋巴瘤模型,随后应用电脉冲通过铂金电极直接刺激肿瘤组织。1周后观察肿瘤大小、转移及存活情况。结果:电脉冲组肿瘤的生长速度、转移程度较对照组低,而死亡率明显低于对照组和化疗组,电脉冲与化疗合用抑制效果更佳。结论:电化学疗法可明显抑制肿瘤组织生长及转移,降低带瘤动物的死亡率。
Objective: To investigate the effect of electrochemical therapy on the inhibitory effect and mortality of TA2 mouse B-cell lymphoma. METHODS: The mouse B-cell lymphoma model was replicated by transplantation, followed by the use of electrical pulses to stimulate the tumor tissue directly through the platinum electrode. Tumor size, metastasis, and survival were observed after 1 week. RESULTS: The growth rate and metastasis of the tumor in the electric pulse group were lower than those in the control group, and the mortality rate was significantly lower than that in the control group and the chemotherapy group. The combination of electric pulse and chemotherapy had a better inhibition effect. Conclusion: Electrochemical therapy can significantly inhibit the growth and metastasis of tumor tissue and reduce the mortality of tumor-bearing animals.