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目的探讨氨氯地平阿托伐他汀钙片治疗高血压合并冠状动脉粥样硬化性心脏病(CHD)患者的临床效果。方法选取2014年3月至2016年3月辽宁省营口市老边区人民医院收治的106例高血压合并CHD患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组53例。观察组患者给予氨氯地平阿托伐他汀钙片治疗,对照组患者给予阿托伐他汀治疗,比较两组患者临床疗效及治疗前后血压、生命质量评分变化,并统计不良反应发生情况。结果观察组患者治疗的总有效率为94.3%,明显高于对照组的81.1%,差异有统计学意义(P<0.05);治疗后,观察组患者的舒张压和收缩压均明显低于对照组,差异均有统计学意义(均P<0.05);治疗后,观察组患者睡眠、精力、躯体活动、社交、疼痛、情绪反应、健康变化维度评分及总评分均明显高于对照组,差异均有统计学意义(均P<0.05);两组患者不良反应发生率差异无统计学意义(P>0.05)。结论氨氯地平阿托伐他汀钙片治疗高血压合并CHD临床疗效显著,可有效控制血压,提高患者生命质量,且不良反应较少,是一种安全、有效的治疗方法。
Objective To investigate the clinical efficacy of amlodipine atorvastatin calcium in patients with hypertension and coronary heart disease (CHD). Methods From March 2014 to March 2016, 106 CHD patients with hypertension in Laobian District People’s Hospital of Yingkou City of Liaoning Province were selected as the research subjects. According to the random number table, they were divided into control group and observation group, with 53 example. Patients in the observation group were treated with atorvastatin calcium tablets of amlodipine. Patients in the control group were given atorvastatin. The clinical efficacy and the changes of blood pressure and quality of life before and after treatment were compared. The incidence of adverse reactions was also calculated. Results The total effective rate of observation group was 94.3%, significantly higher than 81.1% of control group, the difference was statistically significant (P <0.05); after treatment, the patients in observation group had significantly lower diastolic and systolic blood pressure (All P <0.05). After treatment, the dimension, score and total score of sleep, energy, physical activity, social, pain, emotional response and health changes in observation group were significantly higher than those in control group, and the difference was statistically significant (All P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Amlodipine atorvastatin calcium treatment of hypertension with significant clinical effect of CHD, which can effectively control blood pressure, improve patient quality of life, and fewer adverse reactions, is a safe and effective treatment.