青霉胺可能引起毒性反应,但在患风湿性关节炎的病人中,如果其剂量逐渐递增可以减少其副作用。由于铁剂在胃肠道中形成难溶的螯合物而减少青霉胺的吸收。对病人在应用青霉胺引起肾小球性肾炎的关系及其以后撤消铁剂疗法而导致青霉胺剂量的迅速增加的可能性进行了研究。此项研究是对20名患肾小球性肾炎病人中的16名进行了详细的随访。结果表明,其中有7名患者 Penicillamine may cause toxic reactions, but in patients with rheumatoid arthritis, their dose may decrease if their dose increases gradually. Reduction of penicillamine absorption due to iron formation of poorly soluble chelates in the gastrointestinal tract. The possibility of using penicillamine in glomerulonephritis-induced glomerulonephritis and the subsequent rapid increase in the dose of penicillamine was investigated in patients undergoing iron therapy. This study conducted a detailed follow-up of 16 of the 20 patients with glomerulonephritis. The results showed that there were 7 patients