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目的：研制一种口服硝酸甘油控释片。方法：以ＰＶＰ为稳定剂，分别用长链脂肪醇和丙烯酸树脂Ｅ３０Ｄ水分散体包衣，制备硝酸甘油控释片。结果：该片与美国产品Ｎｉｔｒｏｎｇ片（对照品）具有相似的体外释药速率：２ｈ累积释药２２．６７％，６ｈ释药５４．１１％，１２ｈ释药７７．９７％。光、热加速试验及开盘试验结果也显示较高的稳定性。结论：硝酸甘油控释片将有利于心绞痛的治疗，并具有满意的控释作用。
Objective: To develop an oral nitroglycerin controlled release tablets. Methods: With PVP as stabilizer, the long-chain fatty alcohol and acrylic resin E30D aqueous dispersions were respectively coated to prepare nitroglycerin controlled-release tablets. Results: The drug release rate of Nitrong tablet was similar to that of the American product Nitrong tablet (control): 22.67% in 2h, 54.11% in 6h and 77.97% in 12h. Light, thermal accelerated test and opening test results also showed higher stability. Conclusion: The controlled release tablets of nitroglycerin will be beneficial to the treatment of angina pectoris and have satisfactory controlled release.