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神经生长因子(nerve growth factor,NGF)是神经营养因子家族的一种多肽激素,除能促进神经纤维的生长外,还可以通过自分泌和旁分泌的方式作用于某些特定类型的肿瘤组织,影响其发生、发展和转移。在卵巢癌中,NGF通过与其受体TrkA和p75NTR结合而促进肿瘤供给血管的生成,影响细胞因子的水平,在卵巢癌的发生、发展、侵袭和转移中发挥着不可忽略的作用。充分认识NGF的作用机制,将为其在肿瘤早期诊断、治疗及判定预后方面开辟新领域。
Nerve growth factor (NGF), a polypeptide hormone of the family of neurotrophic factors, can not only promote the growth of nerve fibers, but also can act on some specific types of tumor tissues through the way of autocrine and paracrine, Affect its occurrence, development and transfer. In ovarian cancer, NGF promotes tumor-supplied blood vessel formation by binding to its receptors TrkA and p75NTR, influences the level of cytokines, and plays an irreversible role in the occurrence, development, invasion and metastasis of ovarian cancer. Fully understanding the mechanism of action of NGF will open up new fields for its early diagnosis, treatment and prognosis.