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目的探讨成纤维细胞生长因子(FGF)1及FGF受体4(FGFR4)在卵巢子宫内膜异位囊肿发病机制中的作用。方法选择2012年6月至2013年11月在哈尔滨医科大学附属第一医院妇科腔镜病房因卵巢巧克力囊肿(卵巧囊)手术的32例患者为研究组,同期因子宫肌瘤或卵巢畸胎瘤手术的30例患者为对照组。采用免疫组化的方法检测研究组在位内膜及异位内膜和对照组的子宫内膜FGF1和FGFR4的表达情况。结果 (1)FGF1在卵巧囊的在位内膜组、异位内膜组及对照组的阳性表达率分别为37.5%、53.1%、23.3%,三组间差异不具有统计学意义。经两两比较,卵巧囊的异位内膜组与对照组差异具有统计学意义。(2)FGFR4在卵巧囊的在位内膜组、异位内膜组及对照组的阳性表达率分别为59.4%、87.5%、46.7%,组间差异具有统计学意义。结论 FGF1及FGFR4可能有利于卵巢巧克力囊肿的发病及进展。卵巢巧克力囊肿患者的子宫内膜本身可能存在有利于疾病发生的基因,但还不足以致病,后来通过经血逆流至腹腔,在特定的腹腔环境下(如炎症),刺激、加强了致病因子的表达,从而导致了卵巢巧克力囊肿的发病。
Objective To investigate the role of fibroblast growth factor (FGF) 1 and FGF receptor 4 (FGFR4) in the pathogenesis of ovarian endometriosis. Methods Select June 2012 to November 2013 in the First Affiliated Hospital of Harbin Medical University, gynecological laparoscopic ward ovarian chocolate cysts (oocysts) surgery in 32 patients for the study group, the same period due to uterine fibroids or ovarian teratogenic Tumor surgery in 30 patients for the control group. Immunohistochemistry was used to detect the expression of FGF1 and FGFR4 in endometrium and ectopic endometrium and control group. Results (1) The positive rates of FGF1 expression in eutopic endometrium group, ectopic endometrium group and control group were 37.5%, 53.1% and 23.3%, respectively. There was no significant difference among the three groups. After a couple of comparisons, the difference between Ectopic endometrium group and control group was statistically significant. (2) The positive expression rates of FGFR4 in eutopic endometrium group, ectopic endometrium group and control group were 59.4%, 87.5% and 46.7%, respectively. The difference between the two groups was statistically significant. Conclusion FGF1 and FGFR4 may be beneficial to the pathogenesis and progression of ovarian chocolate cysts. Ovarian chocolate cyst in the endometrium itself may have a gene conducive to disease, but not enough to cause disease, and later through the menstrual flow to the abdominal cavity, in a specific peritoneal environment (such as inflammation), stimulate and strengthen the causative agent Of the expression, which led to the incidence of ovarian chocolate cysts.