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目的探讨妊娠期糖尿病(GDM)是否为胰岛素抵抗综合征。方法选择1999-01-2001-12在上海市第一妇婴保健院住院的218例孕妇(均为单胎),分成两组GDM孕妇106例(研究组)、正常孕妇112例(对照组),比较两组孕妇血糖、胰岛素、血脂以及胰岛素敏感指数。结果GDM孕妇100g葡萄糖耐量试验(OGTT)各个时点血糖值高于正常孕妇[空腹(5.13±0.88)mmol/L、(4.37±0.37)mmol/L,1h(11.38±1.48)mmol/L、1h(8.86±1.09)mmol/L,2h(9.98±0.75)mmol/L、2h(7.55±1.07)mmol/L,3h(7.96±1.10)mmol/L、3h(5.83±1.24)mmol/L],差异均有统计学意义(P<0.01);同样GDM孕妇空腹血胰岛素[(15.29±6.48)mU/L、(10.83±9.74)mU/L]、甘油三酯[(4.11±1.42)mmol/L、(2.64±0.76)mmol/L]以及胰岛素敏感指数(4.22±0.48、3.52±0.52)高于正常孕妇(P<0.01)。结论GDM可能是一种胰岛素抵抗综合征。
Objective To investigate whether gestational diabetes mellitus (GDM) is insulin resistance syndrome. Methods Two hundred and eighty-eight pregnant women (all singleton) were hospitalized in Shanghai First Maternal and Child Health Hospital from January 1999 to February 2001. The patients were divided into two groups: 106 pregnant women (study group), 112 pregnant women (control group) The blood glucose, insulin, blood lipid and insulin sensitivity index of two groups were compared. Results The blood glucose level of GDM pregnant women at every time point of 100g glucose tolerance test (OGTT) was significantly higher than that of normal pregnant women [(5.13 ± 0.88) mmol / L, (4.37 ± 0.37) mmol / L, 1h (8.86 ± 1.09) mmol / L, 2h (9.98 ± 0.75) mmol / L, 2h (7.55 ± 1.07) mmol / L, 3h (7.96 ± 1.10) mmol / L and 3h (P <0.01). In the same GDM pregnant women, fasting blood insulin [(15.29 ± 6.48) mU / L, (10.83 ± 9.74) mU / L] and triglyceride [(4.11 ± 1.42) mmol / L , (2.64 ± 0.76) mmol / L] and insulin sensitivity index (4.22 ± 0.48, 3.52 ± 0.52) were higher than those of normal pregnant women (P <0.01). Conclusion GDM may be an insulin resistance syndrome.