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作者以Wilepsol H-15为基质,加5% DL-苯丙氨酸乙酰乙酸乙酯烯胺衍生物(Enamine derivative作为吸收促进剂。主药胰岛素含量为12 U/g。按一次剂量1或2U/kg 给予5只正常狗(10.0±1.0kg)及5只摘除胰腺的狗(10.0±1.1kg,其血糖已高于正常狗)进行实验,同时与含有3%w/w 界面活性剂聚氧乙烯-9-十二烷基醚(BL-9-EX)同剂量的胰岛素栓进行比较。实验前将狗禁食18小时。给药后,定时由肘前静脉取血样,用葡萄糖氧化酶法测定血糖含量,以放射免疫分析法测定胰岛素含量。结果表明,给予含烯胺衍生物的栓剂,剂量1或2U/kg 的正常狗,血糖-时间曲线
The authors used Wilepsol H-15 as matrix and added 5% DL-phenylalanine ethylacetoacetate enamine derivative (absorption enhancer) as the main drug, with an insulin content of 12 U / g and a single dose of 1 or 2 U / kg were administered to 5 normal dogs (10.0 ± 1.0 kg) and 5 pancreatectomized dogs (10.0 ± 1.1 kg, whose blood glucose level was higher than that of normal dogs) and simultaneously with 3% w / w surfactant polyoxygen Ethylene-9-dodecyl ether (BL-9-EX) with the same dose of insulin suppository before the dogs were fasted for 18 hours after the test.After administration, blood samples were taken from the antecubital vein regularly, The blood glucose level was measured and the content of insulin was determined by radioimmunoassay.The results showed that the blood glucose-time curve of suppositories containing enamine derivatives, normal dogs at 1 or 2 U / kg dose