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利扎曲坦(rizatriptan)苯甲酸酯对已克隆的人5-HT1D和5-HT1B受体表现出高选择性亲和力。为评价5-HT1B/1D受体激动剂利扎曲坦和舒马普坦(sumatriptan)对冠状动脉的副作用,分析和比较了两药对离体人脑膜中动脉和冠状动脉的收缩作用。两药均显示对颅脑血管的选择性超出对冠状...
Razzatriptan benzoate showed high selective affinity for cloned human 5-HT1D and 5-HT1B receptors. To assess the side effects of 5-HT1B / 1D receptor agonists rizatriptan and sumatriptan on coronary arteries, the contractile effects of the two drugs on isolated human meninges and coronary arteries were analyzed and compared. Both drugs show the selectivity of the cranial blood vessels beyond the coronary ...