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目的:宫内TORCH感染与新生儿神经行为发育的相关性。方法:选取2011年10月~2013年10月1 650例胎龄为37~42周的新生儿,以检查TORCH系列抗体一项或多项IgM(+),母亲在产前筛查或产时监测TORCH系列抗体一项或多项同种病原体IgM(+)的新生儿作为感染组,对照组为同期检查母亲及新生儿脐血(或外周血)TORCH感染均为阴性的新生儿110例,所有新生儿均在出生后48~72 h、12~14天、26~28天测查NBNA评分。结果:新生儿弓形虫(TOX)、风疹病毒(RUV)、巨细胞病毒(CMV)、疱疹病毒(HSV)感染率比较差异有统计学意义(P<0.05),其中CMV感染率最高(1.58%),其次为RUV(0.73%)、HSV(0.36%)、TOX(0.18%);各时间段RUV和CMV感染组新生儿NBNA评分均低于对照组(P<0.05),TOX和HSV感染组新生儿NBNA评分与对照组相比无统计学差异(P>0.05),各感染组间NBNA评分无明显差异(P>0.05)。同一感染组新生儿NBNA评分在3个时间段比较差异均有统计学意义(P<0.05)。结论:宫内TORCH感染会影响新生儿神经行为的发育,进行医学干预将有助于改善病情。
Objective: To investigate the correlation between intrauterine TORCH infection and neonatal neurobehavioral development. Methods: From January 2011 to October 2013, 1 650 newborns with gestational age of 37-42 weeks were enrolled in order to examine one or more IgM (+) TORCH antibodies and their mothers were tested at prenatal screening or during labor TORCH antibody was used to monitor one or more newborns with one or more of the same pathogens IgM (+) as the infection group. The control group consisted of 110 newborns with negative TORCH infection in both mother and neonatal cord blood (or peripheral blood) All newborns at 48 ~ 72 h after birth, 12 to 14 days, 26 to 28 days to detect NBNA score. Results: The infection rates of TOX, RUV, CMV and HSV in neonates were significantly different (P <0.05), and the infection rate of CMV was the highest (1.58% ), Followed by RUV (0.73%), HSV (0.36%) and TOX (0.18%). NBNA scores in neonates with RUV and CMV infection were significantly lower than those in control (P <0.05) Neonatal NBNA score compared with the control group was no significant difference (P> 0.05), NBNA score between the various infection groups showed no significant difference (P> 0.05). NBNA score of neonates in the same infection group was significantly different in three time periods (P <0.05). Conclusion: Intrauterine TORCH infection can affect the development of neonatal neurobehavior, and medical intervention will help to improve the condition.