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目的:观察家兔角巩膜缘局部应用5-氟尿嘧啶(5-FU)的治疗效果。方法:家兔角巩膜缘区域局部应用5-FU,家兔被立即处死或在7,15,30d后分别处死,处死后即进行组织学检查。结果:在手术刚结束时,所有家兔眼5-FU的应用区域附近都表现为角巩膜组织上皮脱失,术后4d此处区域的溃疡愈合。组织学检查表现为上皮缺失伴轻微水肿。1wk后,2个动物仍表现为上皮缺损、上皮增厚且具有较大的基底细胞、染色质疏松及轻微的上皮下水肿。其余各组没有上述类似改变。结论:角巩膜缘局部应用5-FU能够延迟组织的上皮化。
Objective: To observe the therapeutic effect of 5-fluorouracil (5-FU) on the scleral limbus in rabbits. Methods: 5-FU was applied to the scleral limbus of rabbits. Rabbits were sacrificed immediately or were sacrificed after 7, 15 and 30 days respectively. Histological examination was performed after sacrifice. Results: Immediately after the surgery, the corneal scleral epithelium was lost in the vicinity of the application area of 5-FU in all rabbits, and the ulcer healed in the area 4 days after the operation. Histological examination showed epithelial deletion with minor edema. After 1 week, the two animals still showed epithelial defects, thickening of the epithelium with large basal cells, loose chromatin and slight subepithelial edema. The remaining groups did not have the similar changes described above. CONCLUSIONS: Topical application of 5-FU at the limbus of the limbus delayed tissue epithelization.