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本文评述了心肌镁含量和镁在细胞内的功能及输送机理。早期研究证明,哺乳动物心室肌肉镁含量高,大量是在心肌细胞内,血浆和组织间隙中含量少。大鼠心室肌细胞的镁含量为43.4±0.4mmoles/公斤干重,计算得出每公斤细胞液含镁17.3±0.2mmoles接近于大鼠骨胳肌中镁的含量16.1mmoles。在0℃对大鼠心室肌匀浆按常规分离和测定,证明15%以下的细胞镁与线粒体或肌原纤维相联系,其余的85%以ATP、ADP、AMP镁复合物的形式存在。所以Mg在细胞内的定位直接同ATP和ADP的细胞内定位相一致。大鼠左心室细
This article reviews myocardial magnesium content and magnesium intracellular function and transport mechanism. Early studies have shown that mammalian ventricular muscle magnesium content is high, a large number in the myocardial cells, plasma and interstitial tissue content. The magnesium content of rat ventricular myocytes was 43.4 ± 0.4 mmoles / kg dry weight, and the calculated magnesium content of 17.3 ± 0.2 mmoles per kg of cytosolic solution was close to 16.1 mmoles of magnesium in rat skeletal muscle. Conventional isolation and determination of rat ventricular homogenates at 0 ° C demonstrated that less than 15% of the cells were associated with mitochondria or myofibrils and that the remaining 85% were present as ATP, ADP, and AMP magnesium complexes. Therefore, the localization of Mg in the cells is directly consistent with the intracellular localization of ATP and ADP. Rat left ventricular thin