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目的 :研究流行性乙型脑炎 (乙脑 )患者外周血脂质过氧化物水平变化与病程及预后的关系。方法 :采用硫化巴比妥酸反应产物比色法对 40例乙脑患者外周血过氧化脂质进行检测。结果 :40例患者中轻型与正常对照检测无明显差异 ,重型与极重型脂质过氧化物显著升高 ,脂质过氧化物初热期上升 ,极期达高峰 ,恢复期下降。结论 :乙脑患者病理过程中对中枢神经系统起到了进一步损害作用 ,及时清除自由基对乙脑的病情改善与预后都有积极作用。
Objective: To study the relationship between the changes of peripheral lipid peroxidation and the course and prognosis of patients with Japanese encephalitis (JE). Methods: Peripheral blood lipid peroxidation in 40 patients with JE was detected by thiobarbituric acid reaction product colorimetry. Results: There was no significant difference between light and normal controls in 40 patients. The levels of heavy and heavy lipid peroxides were significantly increased. The lipid peroxides increased in the first heat phase, peaked in the extreme phase, and decreased in the recovery phase. Conclusion: The pathogenesis of JE has further damage to the central nervous system, and timely clearance of free radicals has a positive effect on the improvement and prognosis of JE.