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目的:为了探索牛磺酸(Tau)的增智机理。方法:本文用Morris迷宫学习记忆模型,对大鼠在不同时期补充或抑制牛磺酸的吸收影响大鼠血清中T3、T4及大脑前额叶和海马中Zn含量进行比较。结果:发现适当补充牛磺酸可以提高血清T3及大脑前额叶、海马中Zn的含量,但是没有显著差异,含量的多少与学习成绩好坏基本吻合。而抑制牛磺酸的吸收可以明显降低血清T3的含量,而且与对照组比较有显著差异;抑制牛磺酸的吸收可以降低大脑中前额叶与海马的锌含量,但没有显著差异。结论:缺乏牛磺酸在胚胎初期可降低血清T3含量,从而影响甲状腺激素的合成;由于降低了对学习记忆非常重要的Zn的含量,从而影响了大鼠学习记忆能力。这可能是牛磺酸提高学习记忆能力的部分原因。
Objective: To explore the mechanism of augmentation of taurine (Tau). Methods: Morris maze learning and memory model in rats at different times to supplement or inhibit the absorption of taurine in rat serum T3, T4 and brain prefrontal and hippocampal Zn content were compared. Results: Taurine supplementation was found to increase serum T3 and Zn content in the prefrontal cortex and hippocampus, but there was no significant difference. The content of Taurine was consistent with the academic performance. The inhibition of taurine absorption can significantly reduce the content of serum T3, and compared with the control group were significantly different; inhibition of taurine absorption can reduce the brain in the prefrontal and hippocampal zinc content, but no significant difference. CONCLUSION: The lack of taurine can reduce the content of serum T3 in the early embryo, and thus affect the thyroid hormone synthesis. As a result, the content of Zn, which is important for learning and memory, is decreased, which affects the learning and memory ability of rats. This may be part of the reason why taurine improves learning and memory.