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目的对胸腺五肽反相微乳处方进行筛选并予以评价。方法采用Km值滴定法(Km=m乳化剂∶m助乳化剂)绘制反相微乳各体系的伪三元相图,考察亲水疏水平衡值(hydrophile-lipophile balance number,HLB)、Km值、表面活性剂、助表面活性剂、油相等对反相微乳形成区域及最大载水量的影响,最终确定处方。结果通过绘制伪三元相图,确定微乳的最终处方为油相∶大豆磷脂∶助表面活性剂∶水相=4∶1.67∶3.33∶1,该体系具有较大的W/O型微乳区域及载水量,可将胸腺五肽包裹于水相。结论 Km值、助表面活性剂、油相、表面活性剂对于反相微乳的形成均有影响,在制备过程中应考虑各因素的优化,制得的微乳质量评价符合要求。
Objective To screen thymopentin antimicrobial microemulsion and evaluate it. Methods The pseudo-ternary phase diagram of each system was plotted by Km titration (Km = m emulsifier: m co-emulsifier). The hydrophile-lipophile balance number (HLB) and Km value , Surfactant, co-surfactant, oil phase on the formation of reverse microemulsion and the maximum water carrying capacity, and ultimately determine the prescription. Results By plotting the pseudo-ternary phase diagram, the final formulation of the microemulsion was determined to be the oily phase: soy lecithin: cosurfactant: aqueous phase = 4: 1.67: 3.33: 1, with a larger W / O type microemulsion Regional and water-carrying capacity, thymopentin can be wrapped in the water phase. Conclusion Km, cosurfactant, oil phase and surfactant have influence on the formation of reverse microemulsion. The optimization of each factor should be considered during the preparation. The quality evaluation of microemulsion meets the requirements.