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目的:了解机体免疫功能在糖尿病足的变化,探讨糖尿病足的防治办法。方法:以健康志愿者(ＮＣ)和糖尿病(ＳＤＭ)患者为对照,动态观测糖尿病足(ＤＦ)治疗前及治疗过程中可溶性白介素－Ⅱ受体(ｓＩＬ－２Ｒ)、自然杀伤细胞活性(ＮＫＣＡ)、Ｔ淋巴细胞亚群(ＣＤ３、ＣＤ４、ＣＤ８)、免疫球蛋白(ＩｇＧ、ＩｇＭ、ＩｇＡ)、补体(Ｃ３、Ｃ４、ＣＨ５０)及空腹血糖(ＦＰＧ)、餐后２ ｈ血糖(ＰＧ２ｈ)。结果:①ＤＦ和 ＳＤＭ组ｓＩＬ－２Ｒ显著高于 ＮＣ组(Ｐ＜０．０５),ＮＫＣＡ及 ＣＤ４/ＣＤ８显著低于ＮＣ组(Ｐ＜０．０５);同时ＤＦ患者ｓＩＬ－２Ｒ较ＳＤＭ患者显著增高(Ｐ＜０．０５),ＮＫＣＡ及 ＣＤ４/ＣＤ８ 较ＳＤＭ患者显著降低(Ｐ＜０．０５);在 ＤＦ组中溃疡及坏疽患者 ｓＩＬ－２Ｒ显著高于高危足患者,ＮＫＣＡ显著低于高危足患者(均 Ｐ＜０．０５);②２５例 ＤＦ患者治疗后,ｓＩＬ－２Ｒ逐渐下降,ＮＫＣＡ、ＣＤ４/ＣＤ８逐渐升高,至观察终点与治疗前比较,三者差异均有显著性(Ｐ＜０．０５);③在ＤＦ患者,ｓＩＬ－２Ｒ与病情严重性呈显著正相关(ｒ＝０．７３４,Ｐ＜０．０１),与治疗过程中ＰＧ２ｈ变化亦呈显著正相关(ｒ＝０．４６７,Ｐ＜０．０５),ＮＫＣＡ与ＦＰＧ,ＰＧ２ｈ呈显著负相关(ｒ＝?
Objective: To understand the changes of immune function in diabetic foot and to explore the methods of prevention and treatment of diabetic foot. Methods: The healthy volunteers (NC) and diabetic patients (SDM) were used as control. The levels of soluble interleukin-2 receptor (sIL-2R), natural killer cell activity (NKCA) , T lymphocyte subsets (CD3, CD4, CD8), immunoglobulins (IgG, IgM, IgA), complement (C3, C4, CH50) and fasting plasma glucose (FPG) Results: ① The sIL-2R levels in DF and SDM groups were significantly higher than those in NC group (P <0.05), NKCA and CD4 / CD8 were significantly lower than those in NC group (P <0.05) (P <0.05). The levels of NKCA and CD4 / CD8 in SD patients were significantly lower than those in SDM patients (P <0.05). The sIL-2R levels in patients with ulcer and gangrene in DF group were significantly higher than those in high-risk patients SIL-2R decreased gradually and NKCA and CD4 / CD8 gradually increased after treatment in 25 cases of DF patients. The difference between the two groups was statistically significant (P <0.05) <0.05). ③ In patients with DF, there was a significant positive correlation between sIL-2R and the severity of the disease (r = 0.734, P <0.01), and positively correlated with PG2h in the course of treatment (r = 0.467, P <0.05). There was a significant negative correlation between NKCA and FPG and PG2h (r =?