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目的了解本地区男性不育患者支原体感染状况及耐药情况,为临床合理用药提供参考。方法选取2013年1月-2014年6月金华市妇幼保健院收治的男性不育患者452例作为不育组,另选取生育过1孩及其以上的健康体检男性105例作为对照组,进行精液支原体培养鉴定及药敏分析,统计感染率及耐药性。结果男性不育患者支原体检出率为44.5%,其中解脲脲原体(Uu)感染率为40.0%,人型支原体(Mh)感染率为1.5%,混合感染率为2.9%。不育组仅Uu感染率高于对照组,差异有统计学意义(P<0.05)。药敏结果显示,除强力霉素、美满霉素、交沙霉素尚未有耐药情况出现外,其余均出现不同程度耐药情况,尤其以环丙沙星耐药性为高,对Uu耐药率达56.9%。结论男性不育患者中支原体感染以Uu感染为主。在治疗Uu感染时临床上应首选交沙霉素、美满霉素和强力霉素,减少或避免喹诺酮类药物使用,防止耐药菌株产生。
Objective To understand the prevalence and drug resistance of mycoplasma in male infertility patients in this region and provide references for clinical rational drug use. Methods 452 male infertility patients admitted to Jinhua Maternal and Child Health Hospital from January 2013 to June 2014 were selected as the infertility group. Another 105 healthy male subjects who had one child or more were selected as the control group, Mycoplasma culture identification and drug susceptibility analysis, statistical infection rates and drug resistance. Results The detection rate of mycoplasma in male infertility was 44.5%. The infection rate of Uu was 40.0%, the infection rate of Mh was 1.5% and the infection rate was 2.9%. The infertility group only Uu infection rate was higher than the control group, the difference was statistically significant (P <0.05). Drug sensitivity results show that, in addition to doxycycline, minocycline, josamycin has not yet emerged resistance, the rest are varying degrees of resistance, especially ciprofloxacin resistance is high, Uu resistance Drug rate of 56.9%. Conclusion Mycoplasma infection in male infertility is mainly Uu infection. In the treatment of Uu infection should be the preferred clinical josamycin, minocycline and doxycycline, to reduce or avoid the use of quinolones to prevent drug-resistant strains.