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本实验采用新西兰大耳白兔制作胆道阻塞模型。研究了胆道阻塞以后肝脏抗氧化酶系的变化。结果表明,胆总管结扎二周后肝组织谷胱甘肽过氧化物酶(GPX)只有对照组的30%。超氧化物歧化酶(SOD)下降了50%;谷胱甘肽(GSH)含量也降了50%;而丙二醛(MDA)增加近2倍;红细胞SOD含量明显低于对照组;血清中MDA含量为对照组的4倍。结果提示,胆道阻塞时肝脏抗氧化能力受损,本文对其机理和意义进行了讨论。
In this experiment, New Zealand white rabbits were used to make biliary obstruction model. The change of liver antioxidant enzyme system after biliary obstruction was studied. The results showed that hepatic tissue glutathione peroxidase (GPX) was only 30% of the control group after two weeks of common bile duct ligation. SOD decreased by 50%, glutathione GSH decreased by 50%, while malondialdehyde (MDA) increased by nearly 2 folds. The content of SOD in erythrocytes was significantly lower than that in the control group MDA content of 4 times the control group. The results suggest that the biliary obstruction of the liver impaired antioxidant capacity, the paper discussed its mechanism and significance.