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目的评价两种不同的血管紧张素Ⅱ受体拮抗剂(AngiotensinⅡ receptor blocker,ARB)对冠心病患者支架植入术后再狭窄的影响。方法选择我院2005年6月-2008年6月冠心病支架植入的患者103例,随机分为两组:缬沙坦治疗组(n=54)及氯沙坦治疗组(n=49)。随访并于支架植入术后6个月行冠状动脉造影复查,计算机定量测量病变冠脉狭窄程度,计算再狭窄率及靶血管再次成形率。结果缬沙坦组较氯沙坦组显著降低了支架植入术后6个月再狭窄率(7.4%vs 20.4%,P<0.05)及靶血管成形率(5.6%vs 16.3%,P<0.05)。结论在预防冠脉支架植入术后再狭窄方面,缬沙坦作用强于氯沙坦。
Objective To evaluate the effect of two different angiotensin Ⅱ receptor blockers (ARB) on the restenosis after coronary stenting in patients with coronary heart disease. Methods A total of 103 patients with coronary heart disease undergoing coronary stent implantation in our hospital from June 2005 to June 2008 were randomly divided into two groups: valsartan treatment group (n = 54) and losartan treatment group (n = 49) . Follow-up and coronary angiography were performed 6 months after stent implantation. The degree of coronary artery stenosis was measured by computer, and the rate of restenosis and target vessel reshaping rate were calculated. Results Compared with losartan group, restenosis rate (7.4% vs 20.4%, P <0.05) and target vessel formation rate (5.6% vs 16.3%, P <0.05) ). Conclusions Valsartan is stronger than losartan in preventing restenosis after coronary stenting.