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目的探讨温血诱导心脏停搏及终末温血灌注技术在婴幼儿先天性心脏病（ＣＨＤ）手术中对心肌的保护作用。方法将４０例＜３岁ＣＨＤ患儿随机分成２组：温血诱导心脏停搏＋终末温血灌注组（温血组）；冷晶体液心脏停搏组（冷晶体组）。２组主动脉阻断时间无明显差异；体外循环前、后分别抽血测定乳酸脱氢酶（ＬＤＨ）、肌酸激酶（ＣＫ）、肌钙蛋白Ｔ（ＴｎＴ）；电子显微镜观察两组缺血后心肌超微结构。结果发现冷晶体组ＬＤＨ（１９７．９±７３．６Ｕ／Ｌ），ＣＫ（１０７．６±５０．６Ｕ／Ｌ），ＴｎＴ（８．９±４．０μｇ／Ｌ）升高值均高于温血组（８５．２±４７．７Ｕ／Ｌ，５５．８±３５．９Ｕ／Ｌ和３．３±２．４μｇ／Ｌ，Ｐ＜０．０５），电子显微镜观察缺血后超微结构温血组优于冷晶体组。结论温血诱导心脏停搏及终末温血灌注技术对婴幼儿心肌保护作用有利
Objective To investigate the protective effects of warm-induced cardioplegia and terminal warm-blooded perfusion on myocardium in infants with congenital heart disease (CHD). Methods Forty children with CHD <3 years old were randomly divided into 2 groups: warm-induced cardioplegia + warm-blooded group (warm-blooded group); cold-blooded cardiac arrest group (cold-blooded group). The aorta occlusion time of the two groups had no significant difference. Before and after cardiopulmonary bypass, blood lactate dehydrogenase (LDH), creatine kinase (CK) and troponin T (TnT) Myocardial ultrastructure. The results showed that the elevated values of LDH (197.9 ± 73.6U / L), CK (107.6 ± 50.6U / L) and TnT (8.9 ± 4.0μg / L) Blood group (85.2 ± 47.7U / L, 55.8 ± 35.9U / L and 3.3 ± 2.4μg / L, P <0.05) Blood group is better than cold crystal group. Conclusion Warm blood-induced cardioplegia and terminal warm-blood perfusion technique have a beneficial effect on myocardial protection in infants and young children