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目的观察乳腺癌、胃癌和结直肠癌转移中患者的PRL-3的表达及临床意义。方法检测55例乳腺癌患者(25例无转移灶,30例有淋巴结转移)、60例胃癌患者(35例无转移灶,25例有淋巴结转移)以及60例结直肠癌患者(28例无转移灶,32例有淋巴结转移)外科手术切除标本中PRL-3的表达。结果①乳腺癌淋巴结转移组PRL-3阳性率(86.67%)明显高于无转移灶组(48.00%),P<0.01。②胃癌淋巴结转移组PRL-3阳性率(80.00%)明显高于无转移灶组(48.57%),P<0.05。③结直肠癌淋巴结转移组PRL-3阳性率(56.25%)明显高于无转移灶组(28.57%),P<0.05。结论 PRL-3在肿瘤转移中的高表达表明其与肿瘤转移密切相关,但具体机制尚不十分清楚,仍有一些问题急需解决,而这些问题的解决将有利于揭示PRL-3的功能特性和它促进肿瘤转移的具体机制,从而使PRL-3有可能成为肿瘤治疗及判断肿瘤预后的重要指标及潜在的重要靶点。
Objective To observe the expression and clinical significance of PRL-3 in breast cancer, gastric cancer and colorectal cancer metastasis. Methods Fifty-five breast cancer patients (25 without metastasis, 30 with lymph node metastasis), 60 with gastric cancer (35 without metastasis, 25 with lymph node metastases) and 60 with colorectal cancer (28 without metastasis Stove, 32 cases with lymph node metastasis) in surgical specimens of PRL-3 expression. Results ① The positive rate of PRL-3 in breast cancer with lymph node metastasis (86.67%) was significantly higher than that without metastasis (48.00%), P <0.01. ② The positive rate of PRL-3 in gastric cancer with lymph node metastasis (80.00%) was significantly higher than that without metastasis (48.57%), P <0.05. ③ The positive rate of PRL-3 in colorectal cancer lymph node metastasis group (56.25%) was significantly higher than that in non-metastasis group (28.57%), P <0.05. Conclusions The high expression of PRL-3 in tumor metastasis suggests that PRL-3 is closely related to tumor metastasis. However, the exact mechanism is still unclear, and some problems still need to be solved urgently. The resolution of these problems will help to reveal the functional characteristics of PRL-3 It promotes the specific mechanism of tumor metastasis, so that PRL-3 may become an important indicator of tumor therapy and prognosis of tumor and a potential important target.