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本研究用肌注长效醋酸甲孕酮(DMPA)代替口服去氧炔诺酮用于诱导治疗性闭经(TA),比较血清脂质、脂蛋白及载脂蛋白水平,以评价这两种药物在动脉粥样硬化危险因素中的作用。以78名血压正常、不吸烟的精神障碍妇女和10名男性患者为研究对象。其中33名已接受去氧炔诺酮的患者(不接受抗惊厥药物治疗)随机分为A组(18例)继续用去氧炔诺酮治疗:5～10mg/日,10～12个月。B组(15例)用DMPA代替去氧炔诺酮,开始单次肌注300mg,接着2个月肌注100mg,第3个月肌注150mg,以后每3个月治疗一次,4～6个月和10～12个月抽血化验。另外31例用DMPA治疗,同时接受抗惊厥治疗15例为C组,不接受抗惊厥药物16例为D组。再有14名女性(E组)和10名男性(F组)患者不用上述各种药物,作为对照组。测定TC、HDL-C、TG和ApoA_1、ApoB,LDL-C根据公式计算。进行统计学分析。
In this study, long-acting intramuscular injection of medroxyprogesterone acetate (DMPA) instead of oral norethindrone was used to induce therapeutic amenorrhea (TA), serum lipids, lipoproteins and apolipoproteins were compared to evaluate the efficacy of these two drugs Role in risk factors for atherosclerosis. A total of 78 women with normotensive and nonsmoking mental disorders and 10 male patients were enrolled in this study. Of the 33 patients who had received noroxolaton (not receiving anticonvulsant therapy), they were randomized to Group A (n = 18) to continue treatment with norethisterone: 5 to 10 mg / day for 10 to 12 months. In group B (n = 15), DMPA was used instead of noroxolaton to start a single intramuscular injection of 300 mg followed by intramuscular injection of 100 mg for 2 months and intramuscular injection of 150 mg for the third month, followed by 3 to 6 months of treatment Month and 10 to 12 months of blood tests. Another 31 cases treated with DMPA, while receiving 15 cases of anticonvulsant treatment for the C group, do not accept anticonvulsant drugs in 16 cases for the D group. A further 14 women (group E) and 10 men (group F) did not use the above drugs as controls. Determination of TC, HDL-C, TG and ApoA_1, ApoB, LDL-C calculated according to the formula. Statistical analysis.