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目的通过横断面研究观察我国中老年女性血尿酸(SUA)水平和心律失常风险的关系。方法以2007～2008年我国糖尿病和代谢异常研究数据库中,同时具备SUA和心电图明尼苏达码>50岁的女性为研究对象,按SUA水平分为低、中、高3组。以OR值和Meta分析比较心律失常风险在组间的统计学差异。以Logistic回归和Meta分析校正其他心血管事件危险因素后,比较心律失常风险在不同组间的统计学差异。结果共2172例纳入分析,高尿酸(HSUA)组心律失常风险高于中尿酸(MSUA)组(OR:1.98,95%CI:1.12～3.50)和低尿酸(LSUA)组(OR:1.73,95%CI:1.11～2.71)。校正其他心血管事件危险因素后,HSUA组心律失常风险仍高于MSUA组(校正后OR:2.36,95%CI:1.26～4.39)和LSUA组(校正后OR:1.80,95%CI:1.11～2.90)。MSUA组和LSUA组心律失常风险比较差异无统计学意义(OR:0.84,95%CI:0.55～1.30)。结论高尿酸血症(HUA)与我国中老年女性心律失常独立相关,SUA升高是我国中老年女性危险因素之一。
Objective To observe the relationship between the level of serum uric acid (SUA) and the risk of arrhythmia in Chinese middle-aged and old women by cross-sectional study. Methods From 2007 to 2008, our country’s Diabetes and Metabolic Abnormality Research Database, women with both SUA and ECG Minnesota codes> 50 years of age were divided into low, medium and high groups according to SUA level. Statistical differences in risk of arrhythmia between groups were compared using OR and Meta analysis. After adjusting for other cardiovascular risk factors by Logistic regression and Meta-analysis, the risk of arrhythmia was compared between groups for statistical differences. Results A total of 2172 patients were included in the analysis. The risk of arrhythmia in HSUA group was higher than that in MSUA group (OR: 1.98, 95% CI: 1.12-3.50) and LSUA group (OR: 1.73, % CI: 1.11 ~ 2.71). After adjustment for risk factors for other cardiovascular events, the risk of arrhythmia in the HSUA group was still significantly higher than that in the MSUA group (corrected OR: 2.36, 95% CI: 1.26 to 4.39) and LSUA (adjusted OR: 1.80, 95% CI: 2.90). There was no significant difference in the risk of arrhythmia between MSUA group and LSUA group (OR: 0.84, 95% CI: 0.55-1.30). Conclusions Hyperuricemia (HUA) is independently associated with arrhythmia in middle-aged and elderly women in China. Elevated SUA is one of the risk factors for middle-aged and elderly women in our country.