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目的：探讨中药热敷包治疗膝骨性关节炎导致不良反应的原因及处理措施。方法选取梧州市中医医院2014年12月—2015年11月收治的膝骨性关节炎致不良反应患者103例，均应用中药热敷包治疗，评估其出现的具体不良反应情况及性别分布，分析其发生原因并提出相应处理措施。结果103例患者所发生的不良反应中，以皮肤过敏发生率最高，差异有统计学意义（ P﹤0.05）；而女性患者皮肤过敏发生率高于男性，差异有统计学意义（ P﹤0.05）。结论中药热敷包治疗膝骨性关节炎致不良反应的原因较多，包括热敷温度、性别差异等，医护人员应在治疗期间辅以相应处理措施，以降低中药热敷包治疗膝骨性关节炎致不良反应的发生率，保障中药热敷包治疗膝骨性关节炎的有效性和安全性。“,”Objective To explore the causes and treatment measures of adverse reactions caused by traditional chi-nese medicine hot pack on treating knee osteoarthritis. Methods A total of 103 cases of patients with knee osteoarthritis were selected from December 2014 to November 2015 in the Chinese Medicine Hospital of Wuzhou City,all of patients were treated with traditional chinese medicine hot packs,the adverse reactions and causes were evaluated and analyzed,and raised the corre-sponding treatment measures. Results Skin allergy had highest incidence of adverse reactions of patients(P﹤0. 05);and in-cidence of women was higher than male patients(P﹤0. 05). Conclusion There are many causes of adverse reactions which caused by traditional chinese medicine hot packs in the treatment of knee osteoarthritis, including hot temperature, gender differences,etc. Medical staff should be accompanied by corresponding treatment measures during treatment to reduce the inci-dence of adverse reactions caused by traditional chinese medicine hot packs in treatment of knee osteoarthritis,and protect the ef-fectiveness and security of traditional chinese medicine hot packs on treating knee osteoarthritis.